Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity | Journal of Medicinal Chemistry
Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors | Journal of Medicinal Chemistry
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy | Journal of Medicinal Chemistry
Structure and Mechanism-Guided Design of Dual Serine/Metallo-Carbapenemase Inhibitors | Journal of Medicinal Chemistry
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS) | Journal of Medicinal Chemistry
Discovery of 5-Nitro-6-thiocyanatopyrimidines as Inhibitors of Cryptococcus neoformans and Cryptococcus gattii | ACS Medicinal Chemistry Letters
Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond | Journal of Medicinal Chemistry
Multifunctional Carrier Based on Halloysite/Laponite Hybrid Hydrogel for Kartogenin Delivery | ACS Medicinal Chemistry Letters
Discovery of Potent and Selective 7-Azaindole Isoindolinone-Based PI3Kγ Inhibitors | ACS Medicinal Chemistry Letters
Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase | ACS Medicinal Chemistry Letters
Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators | Journal of Medicinal Chemistry
Structure-Guided Modification of Heterocyclic Antagonists of the P2Y14 Receptor | Journal of Medicinal Chemistry
The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules | Journal of Medicinal Chemistry
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles | ACS Medicinal Chemistry Letters
ACS Medicinal Chemistry Letters | Vol 11, No 11
Discovery of Highly Selective Inhibitors of the Immunoproteasome Low Molecular Mass Polypeptide 2 (LMP2) Subunit | ACS Medicinal Chemistry Letters
Structure–Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists | Journal of Medicinal Chemistry
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria | Journal of Medicinal Chemistry
MOARF, an Integrated Workflow for Multiobjective Optimization: Implementation, Synthesis, and Biological Evaluation | Journal of Chemical Information and Modeling
Synthetic RNA Modulators in Drug Discovery | Journal of Medicinal Chemistry
Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor | ACS Medicinal Chemistry Letters
Forging Odd-Membered Rings: Palladium-Catalyzed Asymmetric Cycloadditions of Trimethylenemethane | Accounts of Chemical Research
Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain | ACS Medicinal Chemistry Letters
Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an In Vivo Model of Trypanosoma cruzi Infection | Journal of Medicinal Chemistry
Scaffold-Hopping Strategy on a Series of Proteasome Inhibitors Led to a Preclinical Candidate for the Treatment of Visceral Leishmaniasis | Journal of Medicinal Chemistry
